Histologie Tumor

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WEB: A Deep Dive into Mesenchymal Tumors

Understanding Glomus Body-Derived Tumors

WEB tumors, a type of mesenchymal tumor, originate from modified smooth muscle cells within the glomus body. These tumors exhibit distinct histological features, including four architectural patterns and two neoplastic cell types.

WHO Tumor Classification and Patterns

The World Health Organization (WHO) categorizes WEB tumors into:

• Glomus tumor: Composed of closely packed, anastomosing vessels
• Glomangioma: Loosely arranged vessels with a myxoid stroma
• Glomangiomyoma: A mixture of glomus tumor and glomangioma patterns
• Glomangiosarcoma: Malignant variant with atypical vessels and high mitotic activity

Neoplastic Cell Types

WEB tumors comprise two neoplastic cell types:

• Glomus cells: Round or polygonal cells with granular cytoplasm
• Myoepithelial cells: Elongated cells with eosinophilic cytoplasm and myofilaments

Prognostic Markers in Colorectal Cancer

In colorectal cancer, tumor deposits (TDs) play a crucial role in prognosis. The presence of TDs is associated with:

• Increased risk of recurrence
• Reduced overall survival

Invasive Lobular Breast Cancer

Invasive lobular breast cancer (ILC) is a distinct type of breast cancer characterized by:

• Lack of distinct cell borders
• Infiltration of surrounding tissue in a single-file pattern
• E-cadherin gene mutation, leading to loss of cell-cell adhesion




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